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A hidden headache culprit
Health Bytes | 20 February, 2009 | Hot Topics:
Q: I recently began taking MSM for my arthritis and immediately realized I was getting terrible headaches. My nutritionist said it was impossible for the two things to be related, but the timing and intensity were too much for me to believe that. Could the MSM be causing them?
Dr. Wright: Yes! And although your letter didn't mention it, there's a strong possibility that you also react to many wines. What's the common factor? MSM (methylsufonylmethane) contains considerable sulphur. Many (although not all) wines contain "sulphite" (SO3) as a preservative.
Sulphur of any sort is eventually metabolised by the enzyme sulphite oxidase in a final common pathway of sulphite to sulphate. Sulphite is quite toxic (babies born with severe sulphite-oxidase deficiency actually die of sulphite toxicity). In all but tiny concentrations, sulphite can definitely cause headaches, as well as dizziness, fatigue, wheezing (sulphite-sensitive asthma), and other symptoms. Sulphate, on the other hand, is the normal "final excretory product," and is entirely non-toxic.
Sulphite oxidase is a molybdenum-dependent enzyme. Without enough of this essential trace element, sulphite oxidase doesn't transform sulphite into sulphate efficiently, excess sulphite builds up, and any or all of the above-noted symptoms can occur. To restore normal sulphur metabolism and eliminate symptoms, what's needed is a molybdenum supplement.
Although there's presently no recommended daily intake for molybdenum, it's a general consensus that if there were one it would be in the neighborhood of 200-300 micrograms daily. However, it's been my experience from many cases that molybdenum absorbs poorly when taken orally. Usually at least 1,000 micrograms twice daily are needed to relieve symptoms and normalise tests (there's a simple urine test available) for sulphite. In a small number of cases, oral supplementation doesn't work and injectable molybdenum is needed.
You may want to try 1,000 micrograms of molybdenum twice daily for at least three to four months and possibly longer. If you still get headaches from MSM after that, you may need injections.
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Editors note
Antoinette Pombo
Health Bytes Editor
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